PUBLICATIONS

 

#Corresponding authorship

*Co-first authorship

  1. Bertholet A.M.*, Natale A.M.*, Bisignano P., Suzuki J., Fedorenko A., Hamilton J., Brustovetsky T., Kazak L., Garrity R., Chouchani E.T., Brustovetsky N., Grabe M.#, and Kirichok Y#. (2022) Mitochondrial Uncouplers Induce Proton Leak by Activating AAC and UCP1. Nature. 606(7912):180-187.

  1. Bertholet A.M. & Kirichok Y. (2022) Mitochondrial H+ Leak and Thermogenesis. Annu Rev Physiol. 10;84:381-407

  1. Bertholet A.M. (2021) The Use of the Patch-Clamp Technique to Study the Thermogenic Capacity of Mitochondria. J Vis Exp. (171).

  1. Allu P.K.R., Paulo E., Bertholet A.M., Situ G., Lee S.H., Wu Y., Gleason C.E., Saha B., Chawla A., Wang B., Pearce D. (2021) Role of mTORC2 in biphasic regulation of brown fat metabolism in response to mild and severe cold. J Biol Chem. 100632.

  1. Bertholet A.M.# & Kirichok Y#. (2020) Patch-Clamp Analysis of the Mitochondrial H+ Leak in Brown and Beige Fat. Front Physiol. 11:326.

  1. Bertholet A.M., Chouchani E.T., Kazak L., Angelin A., Fedorenko A., Long J.Z., Vidoni S., Garrity R., Cho J., Terada N., Wallace D.C., Spiegelman B.M., and Kirichok Y. (2019) H+ transport is an integral function of the mitochondrial ADP/ATP Carrier. Nature 571(7766): 515-520.

Featured in Nature Metab. 2019 Jul 24.

  1. Bertholet A.M.# and Kirichok Y.# (2019) The mechanism of FA-dependent H+ transport by UCP1. Handb Exp Pharmacol 251: 143-159.

                    

  1. Millet A., Merabet N., Bertholet A.M., Daloyau M., Reynier P., Galinier A., Devin A., Wissinger B., Bordeneuve-Guibe J., Belenguer P., and Davezac N. (2017) Imbalance of the REDOX state in dominant Optic Atrophy: the way of mathematical modeling. The Journal of ISANH Vol. 5, Issue 1.

  1. Bertholet A.M., Kazak L., Chouchani E.T., Bogaczynska M., Paranjpe I., Wainwright G.L., Betourne A., Kajimura S., Spiegelman B.M., and Kirichok Y. (2017) Mitochondrial Patch Clamp of Beige Adipocytes Reveals UCP1-Positive and UCP1-Negative Cells Both Exhibiting Futile Creatine Cycling. Cell Metab 25: 811–822.

Featured in Cell Metab. 2017 Apr 4;25(4):761-762.

  1. Bertholet A.M. and Kirichok Y. (2016) UCP1: A transporter for H+ and fatty acid anions. Biochimie. 134: 28-34.

  1. Odegaard J.I.*, Lee M.W.*, Sogawa Y.*, Bertholet A.M., Locksley R.M., Weinberg D.E., Kirichok Y., Deo R.C., and Chawla A. (2016) Perinatal Licensing of Thermogenesis by IL-33 and ST2. Cell 166(4): 841-54.

  1. Millet A., Bertholet A.M., Daloyau M., Reynier P., Galinier A., Devin A., Wissinger B., Belenguer P.#, and Davezac N.# (2016) Loss of functional OPA1 unbalances redox state: implications in dominant optic atrophy pathogenesis. Ann Clin Transl Neurol 3(6):408-21.

  1. Bertholet A.M., Delerue T., Millet A.M., Moulis M.F., David C., Daloyau M., Arnaune-Pelloquin L., Davezac N., Mils V., Miquel M.C., Rojo M., and Belenguer P. (2016) Mitochondrial fusion/fission dynamics in neurodegeneration and neuronal plasticity. Neurobiol Dis 90: 3-19.

  1. Bertholet A.M., Millet A.M., Guillermin O., Daloyau M., Davezac N., Miquel M.C.#, and Belenguer P.# (2013) OPA1 loss of function affects in vitro neuronal maturation. Brain 136(Pt 5):1518-33.

  1. Landes T., Leroy I., Bertholet A.M., Diot A., Khorobakhsh F., Daloyau M., Davezac N., Miquel M.C., Courilleau D., Guillou E., Olichon A., Lenaers G., Arnauné-Pelloquin L., Emorine L.J., and Belenguer P. (2010) OPA1 (dys)functions. Semin Cell Dev Biol 21(6):593-8.

  1. Betourne A., Bertholet A.M., Labroue E., Halley H., Sun H.S., Lorsignol A., Feng Z.P., French R.J., Penicaud L., Lassalle J.M., and Frances B. (2009) Involvement of hippocampal CA3 K(ATP) channels in contextual memory. Neuropharmacol 56(3):615-25.